As we saw from the previews, Selene was captured by Humans and the world knows about Lycan's and Vampires and they are hunted. Selene is frozen for 12 years and wakes up and escapes and she searches for Michael (who may or may not have been captured/killed). She stumbles on this girl that is a Hybrid.
I was worried going in that if Michael was in the movie he would be replaced by another actor since I knew that Scott Speedman was not in the movie. Or I was worried that Michael would not be in the movie at all and that they would kind of forget about him. Well the lack of Michael (other than some flashbacks and some shots of him from far away) was well done and the ending gives you hope that if they make another movie (which I hope they do) that he will definitely be in it.
Selene of course kicks some serious butt and being frozen for 12 years gives her a lower tolerance for anyone's crap. She of course if looking for Michael and asking those that had her kept (a company called Antigen). She instead finds a little girl named Eve, who is a Hybrid. She decides that she needs to protect her while she goes looking for Michael.
I love the introduction of new characters, both Human (Detective Sebastian) and Vampire (David). Also there is new Villains, super huge Lycans. Overall I thought it was a great movie and I will definitely buy it when it comes out on Bluray and see any sequel that comes out.